Endocrine Abstracts

Spermatozoa generate small amounts of O2°- and NO°. Under physiological condition these compounds exist at very low concentration and the formation of peroxynitrite (ONOO−) appears likely. Peroxynitrite reacts rapidly with proteins, lipids and DNA. Moreover, tyrosine nitration is a widely used marker of peroxynitrite. The nitration of protein residues gives rise to 3-nitrotyrosine which represents a protein modification specific for ONOO− formation in ...

Introduction: Within the high prevalence of male infertility there is the rare 45,X/46,XY mosaicism, associated or not with hypogonadism. The phenotypes of this genetical disorder present with a wide variability ranging from Turner stigmata to apparent normal male.Case report: Two men who presented with azoospermia in the context of couple infertility were subsequently found to be affected by 45,X/46,XY mosaicism. Physical examination revealed a complete...